Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics |
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| Authors: | Gilbert Lam Win L. Chiou |
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| Affiliation: | (1) Clinical Pharmacokinetics Laboratory and Department of Pharmacy, College of Pharmacy, University of Illinois at the Medical Center, 60612 Chicago, Illinois |
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| Abstract: | Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed. |
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| Keywords: | drug accumulation steady-state concentrations Michaelis-Menten kinetics zero-order input phenytoin |
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