| 诱导型一氧化氮合成酶与视网膜新生血管形成的关系 |
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| 引用本文： | 芦一. 诱导型一氧化氮合成酶与视网膜新生血管形成的关系[J]. 中国斜视与小儿眼科杂志, 2012, 20(1): 48-48,34 |
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| 作者姓名： | 芦一 |
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| 作者单位： | 200025,上海交通大学医学院研究生院 |
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| 摘 要： | 新生血管生成是缺氧诱导的各种视网膜病变的主要病理变化之一.诱导型一氧化氮合成酶(inducible nitric oxide synthase,iNOS)在此过程中起重要作用,其作用机制错综复杂,且与多种促血管生成因子密切相关.为了阐明iNOS的作用机制,iNOS抑制剂的研究也逐渐受到重视,而使用选择性iNOS抑制剂来抑制视网膜新生血管(Retinal neovascularization,RNV)已成为该领域一大研究热点.本文就iNOS及其抑制剂在RNV形成过程中的作用机制及研究进展进行简要综述.
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| 关 键 词： | 诱导型一氧化氮合成酶(iNOS) 视网膜新生血管(RNV) 选择性iNOS抑制剂 |
Relationship of inducible nitric oxide synthase with retinal neovascularization |
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| Lu Yi. Relationship of inducible nitric oxide synthase with retinal neovascularization[J]. Chinese Journal of Strabismus & Pediatric Ophthalmology, 2012, 20(1): 48-48,34 |
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| Authors: | Lu Yi |
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| Affiliation: | Lu Yi1,Xie Bing2 1 Graduate school,Shanghai Jiaotong University,School of medicine.Class B1170096,227 Chongqing South Road,Shanghai,China 200025. 2 Ophthalmology Department,Ruijin Hospital,Shanghai Jiaotong University,School of medicine.305 Science and Education Plaza,197 Ruijin Er Road,Shanghai,China 200025. |
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| Abstract: | Objective Neovascularization is one of the most common pathological changes of hypoxia retinopathy.Inducible nitric oxide synthase（iNOS） plays an important role in this process,and many angiogenic factors participate in this cascade of angiogenesis.In order to reveal the mechanism,selective iNOS inhibitors have been receiving increasing attentions,and as a result,it also has become an attractive subject to explore the inhibitory effects of different iNOS inhibitors suppressing retinal neovascularization（RNV）.In this article,the mechanism and related findings of iNOS and iNOS inhibitors in the process of RNV will be briefly summarized. |
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| Keywords: | Inducible nitric oxide synthase（iNOS） retinal neovascularization（RNV） selective iNOS inhibitors. |
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