氩氦刀冷冻消融治疗联合肝动脉化疗栓塞术对原发性肝癌生存的影响

目的：观察氩氦刀冷冻消融联合肝动脉化疗栓塞术对原发性肝癌生存的影响。方法：103例中晚期原发性肝癌患者入组；随机分入分入肝动脉化疗栓塞（TACE）组（31例）、氲氦刀冷冻消融组（32例）、TACE联合氩氦刀冷冻消融组（40例）。术后每月复查AFP、T细胞亚群、上腹部CT观察肿瘤坏死情况；随访26个月，观察患者6个月及1年生存率情况。结果：肝动脉化疗栓塞组、氩氦刀冷冻消融组、氩氦刀冷冻消融联合肝动脉化疗栓塞组完全坏死率分别为32．2％、50．0％、50．0％；经统计学检验，P〈0．05，各组之间差异具有统计学意义。1年生存率分别为54．8％、56．2％、75．0％，联合治疗组较单纯TACE组和氩氦刀冷冻消融组明显提高，差异具有统计学意义。结论：TACE联合氩氦刀冷冻消融更有利于改善患者长期生存，不良反应可耐受。

Clinical Observation of Cryosurgery Combined with TACE on the Survival of Advanced Primary Hepatic Carcinoma

Objective： To observe the effect of survival of advanced primary hepatic carcinoma therapy by cryosurgery combined with TACE. Methods ：103 patients with advanced primary hepatic carcinoma were enroUed; randomly divided into seqtiential TACE group, cryosurgery group, and cryosurgery se- quential TACE group. After the monthly review AFP, T cell subsets, abdominal CT on the tumor nec- rosis; follow- up 26 months to observe the survival time of patients. Results：The complete necrosis rate were 32. 2%, 50. 0% ,50. 0% in TACE group , cryosurgery group, and cryosurgery sequential TACE group, statistical analysis showed significant difference. 1 -year survival rates were 54. 8%, 56.2%, 75.0%, combination therapy group than in TACE alone group and cryoablation ablation group was significantly increased, the difference was statistically significant. Conclusions： TACE combined with cryosurgery is more conducive to improved long -term survival and the adverse reac- tions can be tolerated.