表没食子儿茶素没食子酸酯对局灶性脑缺血-再灌注损伤的影响

目的探讨表没食子儿茶素没食子酸酯（EGCG）对大鼠脑缺血-再灌注损伤的预防作用。方法通过建立大鼠大脑中动脉阻断模型,观察EGCG对脑缺血-再灌注损伤时神经功能缺损评分,脑组织含水量、乳酸含量、能量代谢酶活性的影响。结果 EGCG能使神经功能缺损评分分值明显降低,脑组织含水量、脑组织乳酸含量有所减少,Na＋-K＋-ATP酶活性升高,与模型组相比差异有显著性（P〈0.05）。结论 EGCG对大鼠局灶性脑缺血-再灌注引起的神经损伤有预防作用,机制可能与其改善脑细胞代谢、减轻脑水肿有关。

Effects of EGCG on Focal Cerebral Ischemia-Reperfusion Injury in Rats

Objective To study the protective effects of epigallocatechin gallate （EGCG） on focal cerebral ischemia-reperfusion injury in rats. Methods To build the animal model of focal cerebral ischemia-reperfusion injury by the middle cerebral artery occlusion （MCAO）. The evaluations of neurological function were scored＇ by Longa score method; the brain tissue water content was measured with drywet quality method;the content of lactic acid（LA） and the activity of Na＋ -K＋ -ATPase in brain tissue were detected. Results Compared with ischemia- reperfusion group, EGCG treatment exhibited the remarkable reduction in neurologic deficit scores, somewhat decrease of water content and LA in brain tissue and significant increase of the Na＋- K＋ATPase activity, which showing significant difference（ P 〈 0. 05）. Conclusion EGCG has the protective effect on cerebral ischemiareperfusion injury in rats. The mechanism might be related to decrease brain edema and improve brain cell metabolism.