| 探讨骨骼肌细胞葡萄糖转运蛋白4含量在早发2型糖尿病患者中的特点 |
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| 引用本文： | 周少玲,高伟,史虹莉,方京冲,陆肇增,祝禾辰. 探讨骨骼肌细胞葡萄糖转运蛋白4含量在早发2型糖尿病患者中的特点[J]. 中国现代医学杂志, 2008, 18(16): 2377-2379,2382 |
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| 作者姓名： | 周少玲 高伟 史虹莉 方京冲 陆肇增 祝禾辰 |
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| 作者单位： | 1. 青岛大学医学院附属烟台毓璜顶医院,内分泌科,山东,烟台,264000
2. 复旦大学附属华山医院,内分泌科,上海,200040 |
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| 摘 要： | 目的 探讨骨骼肌细胞葡萄糖转运蛋白4(GLUT4)蛋白含量在早发2型糖尿病(T2DM)患者中的特点.方法 试验共分为4组:年轻非糖尿痛对照组(YN),老年非糖尿病对照组各6例(ON);早发T2DM(EOD)和晚发T2DM各8例(LOD),手术前当天抽取患者空腹血,测定FPG、HbA1c、FINS;手术中取骨骼肌组织约500 mg,应用Western blot方法测定各组骨骼肌细胞GLUT4蛋白含量.结果 糖尿病组的FPG和HbA1c水平均高于非糖尿病对照组,EOD组患者血糖和HbA1c高于LOD组,差异有显著性;糖尿病组中的GLUT4蛋白含量低于非糖尿病对照组(P<0.05);EOD组中骨骼肌细胞GLUT4蛋白含量高于LOD组(P<0.05);通过相关分析发现,在糖尿病组中骨骼肌GLUT4蛋白水平和WHR、HOMAIR以及腰围呈负相关.结论 骨骼肌细胞GLUT4蛋白含量降低,在2型糖尿病人胰岛素抵抗的发生过程中起到了一定的作用;早发2型糖尿病人胰岛素抵抗程度较轻,可能和骨骼肌细胞中GLUT4含量较高有关.
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| 关 键 词： | 早发 晚发 2型糖尿病 胰岛素抵抗 葡萄糖转运蛋白4 |
Investigation on changes of skeletal muscle cells glucose transporter 4 in early-onset type 2 diabetes mellitus |
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| ZHOU Shao-ling,GAO Wei,SHI Hong-li,FANG Jing-chong,LU Zhao-zeng,ZHU He-chen. Investigation on changes of skeletal muscle cells glucose transporter 4 in early-onset type 2 diabetes mellitus[J]. China Journal of Modern Medicine, 2008, 18(16): 2377-2379,2382 |
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| Authors: | ZHOU Shao-ling GAO Wei SHI Hong-li FANG Jing-chong LU Zhao-zeng ZHU He-chen |
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| Affiliation: | ZHOU Shao-ling1,GAO Wei1,SHI Hong-li2,FANG Jing-chong2,LU Zhao-zeng2,ZHU He-chen2 (1.Department of Endocrinology,the Affiliated Yuhuangding Hospital of Qingdao University Medical College,Yantai,Sh,ong 264000,P.R.China,2.Department of Endocrinology,the Affiliatted Huashan Hospital of Fudan University,Shanghai 200010. P.R. China) |
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| Abstract: | [Objective] To investigate glucose transporter 4(GLUT4) protein content in skeletal muscle cells of early-onset T2DM and to evaluate its potential molecular mechanism in the pathogenesis of early-onset T2DM. [Methods] Totally 28 patients given opportunity selected operation were enrolled and all agreed the consent. They were divided into four groups: Young non-diabetic control group (YN, n =6), Old non-diabetic control group (ON, n=6), Early-onset T2DM group(EOD, n =8), Late-onset T2DM group (LOD, n =8). Th... |
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| Keywords: | early-onset late-onset type 2 diabetes mellitus insulin resistance glucose transporter 4 |
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