Successful unrelated donor cord blood transplantation for chronic granulomatous disease |
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| Authors: | Tang-Her Jaing Wen I Lee Po-Jen Cheng Shih-Hsiang Chen Jing-Long Huang Yung-Kuei Soong |
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| Affiliation: | (1) Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan;(2) Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan;(3) Lin-Kou Medical Center, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, 333 Taoyuan, Taiwan; |
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| Abstract: | This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable. |
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