The environment within: how gut microbiota may influence metabolism and body composition |
| |
| Authors: | A Vrieze F Holleman E G Zoetendal W M de Vos J B L Hoekstra M Nieuwdorp |
| |
| Institution: | (1) Department of Internal and Vascular Medicine, Academic Medical Centre, Meibergdreef 9, room F4-159.2, 1105, AZ, Amsterdam, the Netherlands;(2) Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands;(3) Department of Basic Veterinary Medicine, University of Helsinki, Helsinki, Finland;(4) Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands; |
| |
| Abstract: | Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide.
The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of
energy expenditure through decreased physical activity. In addition, recent studies have focused on intestinal microbiota
as environmental factors that increase energy yield from diet, regulate peripheral metabolism and thereby increase body weight.
Obesity is associated with substantial changes in composition and metabolic function of gut microbiota, but the pathophysiological
processes driving this bidirectional relationship have not been fully elucidated. This review discusses the relationships
between the following: composition of gut microbiota, energy extracted from diet, synthesis of gut hormones involved in energy
homeostasis, production of butyrate and the regulation of fat storage. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
