Generation of a panel of antibodies against proteins encoded on human chromosome 21 |
| |
| Authors: | Frances K Wiseman Olivia Sheppard Jacqueline M Linehan Sebastian Brandner Victor LJ Tybulewicz Elizabeth MC Fisher |
| |
| Institution: | (1) Department of Neurodegenerative Disease, UCL Institute of Neurology, WC1N 3BG Queen Square, London, UK;(2) MRC National Institute for Medical Research, The Ridgeway, NW7 1AA Mill Hill, London, UK |
| |
| Abstract: | Background Down syndrome (DS) is caused by trisomy of all or part of chromosome 21. To further understanding of DS we are working with
a mouse model, the Tc1 mouse, which carries most of human chromosome 21 in addition to the normal mouse chromosome complement.
This mouse is a model for human DS and recapitulates many of the features of the human syndrome such as specific heart defects,
and cerebellar neuronal loss. The Tc1 mouse is mosaic for the human chromosome such that not all cells in the model carry
it. Thus to help our investigations we aimed to develop a method to identify cells that carry human chromosome 21 in the Tc1
mouse. To this end, we have generated a panel of antibodies raised against proteins encoded by genes on human chromosome 21
that are known to be expressed in the adult brain of Tc1 mice |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
