IL-18、NO、ET对评价冠脉粥样硬化狭窄程度的临床价值

目的：探讨IL-18、NO、ET检测对冠心病（CHD）患者冠脉狭窄程度的临床价值。方法：检测冠状动脉不同狭窄程度CHD患者外周血IL-18、NO、ET的含量。结果：重度狭窄组IL-18、ET含量高于中度狭窄组（P〈0.05）,NO含量低于中度狭窄组（P〈0.05）;中度狭窄组IL-18、ET含量高于轻度狭窄组（P〈0.05）,NO含量低于轻度狭窄组（P〈0.05）;轻度狭窄组IL-18、ET含量高于正常对照组（P〈0.05）,NO含量低于正常对照组（P〈0.05）。结论：临床可通过检测CHD患者血浆中IL-18、NO、ET的含量,作为评价冠脉狭窄程度严重程度的指标。

The Clinical Usefulness of Determination of Plasma IL-18, NO and ET Levels for Assessment of Degree of Arterial Stenosis in Patients with Coronary Heart Disease

Objective To study the clinical value for assessment of the degree of arterial stenosis with determination of plasma IL-18,NO and ET levels in patients with coronary heart disease（CHD）.Methods plasma IL-18,NO（with ELISA）and ET（with RIA）levels were determined in 115 patients with CHD（mild stenosis,n=44,moderate stenosis,n=41,severe stenosis,n=30）and 60 controls.Results The plasma levels of IL-18 and ET in patients with severe stenosis were significantly higher than those in patients with moderate stenosis,while the plasma NO levels were significantly lower（P〈0.05）.The plasma levels of IL-18 and ET in patients with moderate stenosis were significantly higher than those in patients with mild stenosis and the plasma NO levels were significantly lower（P〈0.05）.Again,the same was true for the plasma levels of the three markers in patients with mild stenosis and controls（P〈0.05）.Conclusion Determination of plasma IL-18,NO and ET levels might be used as an adjuvant non-invasive method for assessment of the degree of arterial stenosis in patients with coronary heart disease.