小儿肾脏疾病尿微量蛋白动态变化与临床转归

本文应用 ELISA 法测定68例小儿肾脏及相关疾病四种尿微量蛋白:白蛋白(ALb)、免疫球蛋白(IgG、IgA、Igm)的变化,并观察预后。发现肾炎组 AIb、IgG 明显增高(P<0.05),且微量蛋白增高者病程长平均53天,而正常者平均34天;肾病组四种均高,尤以 AIb最明显(P<0.01),微量蛋白升高明显者86%复发,53%对激素无效应或部分效应;过敏性紫癜仅 Alb 和 IgA 增高(P<0.05),增高者73%发生肾损害。结果表明尿微量蛋白的测定有助于判定预后也是判定最终治愈的标准之一。

Dynamic change and clinical character of urinary microprotein in renal disease in children

The change of four kinds of urinary microprotein(ALb,IgG,IgA ,IgM)was measured in 68 children with renal or renal associater disease by ELISA technique,and the prognosis observed.It was found that in glomerulonephritis group,ALb and IgG increased greatly,(P<0.05)and the average course of disease was 53 days in high microprotein persons and 34 days in normal;in nephrotic syndrome,all the microprotein increased with ALb most significant(P<0.01),and re- plasing happened in 86 percent in high microprotein group,with having no or partial effect to hor- mone in 53 percent;in anaphylactic purpura,only IgA and ALb rised(P<0.05)and renal lesion happened in 73 percent in high ones.It was shown that the measurement of urinary microprotein was benefit for Judgment of prognosis.