呼吸内科病房泛耐药鲍曼不动杆菌的耐药性及临床用药分析

目的：了解2010-2012年间本院呼吸科病房泛耐药鲍曼不动杆菌（PDR-Ab）对常用抗菌药物的耐药情况及耐药性变化，指导临床合理用药。 方法：回顾性分析本院呼吸科2010-2012年间分离的283株泛耐药鲍曼不动杆菌的药敏结果及阳性检出率，药敏结果采用K-B纸片琼脂扩散法。 结果：泛耐药鲍曼不动杆菌对临床常用14种抗菌药物均有不同程度的耐药，且呈逐年上升的趋势，对碳青酶烯类上升幅度最大；其中耐药率最高的是头孢他啶，达93.4% ；耐药率最低的是多粘菌素B，仅1.9%；其次，对亚胺培南，头孢哌酮/舒巴坦，氨苄西林/舒巴坦，米诺环素，阿米卡星等耐药率相对较低 结论：来源于本院呼吸内科病房的泛耐药鲍曼不动杆菌对临床常用抗菌药物耐药率很高，临床必需加强耐药监测，以便为临床合理用药提供理论和客观依据。

drug resistance and clinical uses analysis of pan-drug resistant Acinetobacter baumannii in the respiratory department

Objective : To investigate the clinical medicine and drug resistance of pan-drug resistant Acinetobacter baumannii in the respiratory department in order to offer reference for the clinical therapeutics. Methods: The 283 strains of pan-drug resistant Acinetobacter baumannii were retrospective statistical analyzed about the result of sensitivity to antibiotics in the respiratory department from 2010 to 2012.The disk diffusion method was employed to detect the drug-resistance ratio. Results: Clinical infection of pan-drug resistant Acinetobacter baumannii had various degree of drug-resistance rate to fourteen different antibiotic agents,The highest rate of drug-resistance ratio was ceftazidime(93.4%)and the lowest of drug-resistance ratio to imipenem was 1.9%.Tne drug-resistance ratio of imipenem, cefoperazone/sulbactam, ampicillin/sulbactam , minocycline, amikacin and so on were low by comparision. Conclusion: Clinical infection of pan-drug resistant Acinetobacter baumannii had rather high drug-resistance rate to fourtheen different antibiotic agents in the respiratory department . More attention shoud be paid to provide theoretical and objective basis for clinical uses rationally.