| 乳腺癌干细胞的研究进展 |
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| 引用本文： | 刘明明,杨恭. 乳腺癌干细胞的研究进展[J]. 中国癌症杂志, 2013, 23(8): 624-636. DOI: 10.3969/j.issn.1007-3969.2013.08.011 |
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| 作者姓名： | 刘明明 杨恭 |
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| 作者单位： | 复旦大学附属肿瘤医院肿瘤研究所，上海市乳腺癌重点实验室，复旦大学上海医学院肿瘤学系，上海 200032 |
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| 摘 要： | 乳腺癌干细胞是一类具有自我更新能力、多向分化潜能和高度致瘤能力的细胞亚群，与乳腺癌的发生、发展、复发、转移以及治疗抵抗等密切相关。现就近年来乳腺癌干细胞的研究进展作一综述。
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| 关 键 词： | 乳腺癌 干细胞 信号通路 小干扰RNA |
The recent advances in breast cancer stem cells |
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| LIU Ming-ming,YANG Gong. The recent advances in breast cancer stem cells[J]. China Oncology, 2013, 23(8): 624-636. DOI: 10.3969/j.issn.1007-3969.2013.08.011 |
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| Authors: | LIU Ming-ming YANG Gong |
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| Affiliation: | Cancer Institute, Fudan University Shanghai Cancer Center, the Key Laboratory of Breast Cancer of Shanghai, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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| Abstract: | Breast cancer stem cells comprise a sub-population, which enables the capacity for self-renewal and the potentiality for differentiation and high tumorigenicity. Growing evidence suggests that breast cancer stem cells most likely contribute to tumor generation, progression, relapse, metastasis and therapeutic resistance. Herein, the recent advances in breast cancer stem cells were highlighted in this review. |
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| Keywords: | Breast cancer Stem cell Signaling pathway miRNA |
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