ERα、ERβ在非吸烟非小细胞肺癌患者中的表达与生存期和性别的相关性研究

背景与目的：雌激素信号传导在非小细胞肺癌(non-small cell lung cancer，NSCLC)中存在争议，体外实验发现，雌激素受体(estrogen receptor，ER)ERβ与肺内组织的异常增生相关，ERβ在正常组织和肺癌组织中的表达结果不同。本研究旨在探讨ERα和ERβ在非吸烟NSCLC患者中的表达与临床病理特征和生存期的关系。方法：收集有组织学病理诊断的144例非吸烟的NSCLC组织及其临床资料，免疫组化方法检测ERα和ERβ表达状况并分析与临床特点和生存期的关系。结果：ERα阳性表达率为7.6%，仅在腺癌中表达，ERα表达状态与生存期无关。ERβ表达率为52.1%，Ⅰ、Ⅱ期患者的表达显著高于Ⅲ、Ⅳ期，差异有统计学意义(P=0.020)。ERβ表达阳性和阴性的中位生存期(median survival time，MST)分别为43和38个月，差异有统计学意义(P=0.028)，ERβ表达阳性和阴性的女性MST分别为45和37个月，差异有统计学意义(P=0.033)。在腺癌中ERβ阳性和阴性表达的MST分别为46和38个月，差异有统计学意义(P=0.021)。结论：ERβ在早期非吸烟NSCLC中表达增高，是女性、腺癌生存期良好的标志。

Relationships between survival and expressions of estrogen receptor α and β in non-smoking nonsmall cell lung cancer patients

Background and purpose: The involvement of estrogen signaling in lung cancer is controversial. But the findings showed that ERβ might play an important role in neoplastic lung biology. Several studies have evaluated expression of ERβ in both normal and neoplastic human lung tissues with variable conclusions. We aimed to evaluate the expressive of estrogen receptors (ER) α, β in non-smoking non-small cell lung cancer (NSCLC) and investigate the relationships between the survival and expressions of ERα, β. Methods: Immunohistochemical assay was used to detect the expression ERα and ERβ in 144 NSCLC patients, and analyzed the expressions status of ERα, β and survival. Results: The positive rate of ERα was 7.6%, only in adenocarcinoma cancer. The positive rate of ERβwas 52.1%, and the expressions of stage Ⅰ and Ⅱ was significantly higher than that of stage Ⅲ and Ⅳ (P=0.020). The median survival time (MST) of ERβ positive expression was better than that of negative expression (43 months vs 38 months, P=0.028). The MST of ERβ positive expression of female patients was better than that of negative expression (45 months vs 37 months, P=0.033). The MST of ERβ positive expression of adenocarcinoma were 46 months and better than negative 38 months (P=0.021). Conclusion: The expression of ERβ was significantly higher in early-stage non- smoking NSCLC. It indicated that the positive expression of ERβ was related to the better MST, especially in female adenocarcinoma patients.