MMP-3基因多态性对冠状动脉介入术后再狭窄的影响

【摘要】目的探讨基质金属蛋白酶-3（MMP-3）启动子区域5A/6A基因多态性是否参与了经皮冠状动脉介入治疗（PCI）术后再狭窄发生发展过程。方法入选行PCI治疗术后复查的冠状动脉造影患者437例。收集患者复查冠状动脉造影前、后临床资料及造影结果，并留取血标本进行血清MMP-3含量以及基因多态性分析。根据MMP-3基因表型不同，分为突变组（5A/5A+5A/6A，n=136）和野生组（6A/6A，n=301）。比较2组相关资料，分析基因多态性与再狭窄的关系。结果2组再狭窄率差异无统计学意义（42.2%vs33.1%，P＞0.05）。与突变组比较，野生组再狭窄程度[ （56.28±11.10）%vs （36.00±10.17）%]较高（P＜0.01）；2组血清MMP-3含量[ （13.38±3.00）μg/Lvs（12.33±2.96）μg/L]差异无统计学意义（P＞0.05）。携带6A等位基因患者再狭窄率要高于携带5A等位基因患者（P＜0.05）。携带野生基因型是PCI术后再狭窄的危险因素。结论携带6A等位基因患者再狭窄风险性明显高于携带5A等位基因患者

Effects of MMP-3Gene Polymorphism in Restenosis after Percutaneous Coronary Interventions

[Abstract]Objective To investigate the relationship between matrix metalloproteinase-3(MMP-3) gene promoterpolymorphisms5A/6A and the restenosis after percutaneous coronary intervention (PCI).MethodsA total of437 patients with PCI were selected in this study. Patients were divided into mutant genotype group (5A/5A+5A/6A,n=136) and wild genotype group (6A/6A,n=301) according to MMP-3polymorphism. The angiography and clinic data were collected before and after coronary angiography in two groups of patients. The serum level MMP-3and genotype analysis were compared between two groups.ResultsThere was no significant difference in the restenosis rate between two groups (42.2%vs33.1%,P＞0.05). The restenosis degree was significantly higher in wild genotype group than that in mutant genotype group (56.28%±11.10%vs36.00%±10.17%,P＜0.01). There was no significant difference in the serum level of MMP-3between two groups(13.38μg/L ±3.00μg/Lvs12.33μg/L±2.96μg/L,P＞0.05). There was a higher restenosis rate in patients carrying 6A allele than that of patients carrying 5A allele (P＜0.05). Carrying wild genotypes are risk factors for restenosis after PCI.ConclusionPatients carrying6A allele have significantly higher risk of resteonsis than patients carrying5A allele