Quantitative study of germinal center area in normal and diseased tonsils using image analysis |
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Authors: | Gorfien J L Hard R Noble B Brodsky L |
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Affiliation: | Department of Microbiology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and Children's Hospital of Buffalo 14214, USA. |
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Abstract: | The aim of this study was to measure the germinal center area of secondary follicles in a consistent and unbiased manner using image analysis. Tonsil specimens were obtained from children with clinical evidence of recurrent tonsillitis and/or idiopathic tonsillar hypertrophy. Normal control biopsy specimens were obtained from children with no history of ear, nose, or throat infections. The results show a significant increase in the germinal center area in tonsils exhibiting hypertrophy when compared to normal controls (p < .002). Image analysis is an important tool for making quantitative size comparisons in lymphoid tissues. |
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