| 不同基因型丙型肝炎病毒Core蛋白HLA-DRBl^＊0311、0401表位预测 |
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| 引用本文： | 程玲,洪国祜,郭艳,毛青. 不同基因型丙型肝炎病毒Core蛋白HLA-DRBl^＊0311、0401表位预测[J]. 临床肝胆病杂志, 2011, 27(1): 61-64 |
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| 作者姓名： | 程玲 洪国祜 郭艳 毛青 |
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| 作者单位： | 第三军医大学西南医院全军感染病研究所,重庆,400038 |
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| 基金项目： | 国家自然科学基金(30771840) |
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| 摘 要： | 目的预测各型丙型肝炎病毒（HCV）Core区的人类白细胞抗原（HLA）-DRB1＊0311及0401抗原表位。方法从NCBI数据库中检索出十条包含六种分型的HCV完整氨基酸序列,使用生物信息学工具剪切Core区氨基酸序列并对其二级结构、可塑性、亲水性和抗原性指数进行预测,选择可能区域预测HLA-DRB1＊0311及0401的抗原表位。结果 HCV Core区二级结构、可塑性、亲水性和抗原性指数预测分析可认为16～28、60～74、98～120区域或为抗原表位区域。HLA-DRB1＊0311预测中,HCV-1a/b、4a、6a预测评分高的区域为28～36,HCV-2a/b为63～71,HCV-3a为29～37,HCV-5a为94～102。HLA-DRB1＊0401中,HCV-1a、2b、4a、6a预测评分高区域为84～92,HCV～5a为120～128,HCV-1b中120～128可以预测到表位但评分低。结论 HCV Core区HLA-Ⅱ类分子抗原表位具有型间差异。
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| 关 键 词： | 肝炎病毒属 病毒核心蛋白质类 基因型 表位 |
Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes |
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| CHENG Ling,HONG Guo-hu,GUO Yan,et al.. Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes[J]. Chinese Journal of Clinical Hepatology, 2011, 27(1): 61-64 |
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| Authors: | CHENG Ling HONG Guo-hu GUO Yan et al. |
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| Affiliation: | CHENG Ling,HONG Guo-hu,GUO Yan,et al.(PLA Institute of Infectious Diseases,Southwest Hospital,the Third Military Medical University,Chongqing 400038,China) |
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| Abstract: | Objective To predict the epitopes of hepatitis C virus(HCV) core protein of different genotypes,which can be recognized by HLA-DRB1*0311/0401.Methods Ten complete amino acid sequences of HCV were searched from NCBI database,which contain six genotypes of HCV.Core sequences were selected to predict secondary structure,flexiblity,hydrophilicity,antigen index and then predict the HLA-DRB1*0311/0401 in recognizing epitopes.Results The probable regions of epitopes according to the secondary structure,flexiblity,... |
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| Keywords: | hepacivirus viral core proteins genotype epitopes |
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