中国老年人群轻度认知障碍患病率及发展趋势的Meta分析

背景 随着我国老龄化进程的加快，轻度认知障碍（MCI）已成为影响老年人生活质量的重要疾病，了解其患病率对于推进健康老龄化有重要意义，但近10年尚缺乏大样本调查数据对全国老年人群MCI患病率进行全面报道。 目的 了解近10年中国老年人群MCI患病率及发展趋势，为进一步开展老年公共服务政策研究提供数据支撑。 方法 2021年1月，检索中国生物医学文献数据库、维普网、万方数据知识服务平台、中国知网、PubMed、Ovid、Springer Link、EmBase等数据库，获取发表时间为2010年1月至2020年12月的中国老年人群MCI患病率的原始研究文献。提取文献中的患病率相关数据，根据异质性检验结果选择相应模型合并效应指标。 结果 本研究共纳入47篇文献，样本量共计137 599。近10年中国老年人群MCI总体患病率为19%〔95%CI（17%，21%）〕。人口学分析结果显示：男性和女性老年人群MCI患病率分别为17%〔95%CI（15%，19%）〕和19%〔95%CI（17%，21%）〕；城市和农村地区老年人群MCI患病率分别为16%〔95%CI（11%，22%）〕和23%〔95%CI（16%，30%）〕；有配偶和无配偶的老年人群MCI患病率分别为16%〔95%CI（14%，19%）〕和24%〔95%CI（20%，28%）〕；60~64岁老年人群MCI患病率为13%〔95%CI（9%，17%）〕，65~69岁为12%〔95%CI（9%，15%）〕，70~74岁为17%〔95%CI（13%，20%）〕，75~79岁为26%〔95%CI（20%，31%）〕，80~84岁为33%〔95%CI（24%，42%）〕，≥85岁为42%〔95%CI（22%，62%）〕；我国老年人群MCI患病率随教育程度增长而降低，文盲组（受教育年限<1年）MCI患病率为30%〔95%CI（25%，35%）〕，大学组（受教育年限>12年）的患病率下降为10%〔95%CI（7%，13%）〕。空间分布结果：各省份之间老年人群MCI患病率差异明显（15%~37%），各区域之间差异明显（17%~22%）。时间分布结果：近10年老年人群MCI患病率呈增长趋势（11%~28%）。 结论 近10年中国老年人群MCI患病率呈增长趋势，不同省份、区域之间存在差异。另外，女性、受教育程度低、高龄、农村、无配偶群体患病率偏高。 该文的微信推文请扫描下方二维码查看！

Prevalence and Distribution Trends of Mild Cognitive Impairment among Chinese Older Adults:a Meta-analysis

Background Mild cognitive impairment(MCI)has become a major disorder affecting the quality of life of Chinese older adults,a rapidly increasing population.Understanding MCI prevalence in this population is important for promoting healthy ageing,but there is a lack of comprehensive reports on MCI prevalence in a large national sample of older adults in the past decade.Objective To examine the trends of MCI prevalence and geographical distribution in Chinese older adults in the past 10 years,providing data support for further research on public service policies for the elderly.Methods In January 2021,we searched for studies about MCI prevalence in Chinese older adults published from January 2010 to December 2020 from databases of SinoMed,CQVIP,Wanfang Data,CNKI,PubMed,Ovid,SpringerLink,and EmBase,and extracted data regarding MCI prevalence from the eligible ones,then chose effects models with indicators based on the within-study heterogeneity.Results A total of 47 studies were included,involving 137599 samples.The overall prevalence of MCI in Chinese older adults in the last decade was 19%〔95%CI(17%,21%)〕.Demographic analysis showed the following results:the MCI prevalence was 17%〔95%CI(15%,19%)〕and 19%〔95%CI(17%,21%)〕for men and women,respectively,16%〔95%CI(11%,22%)〕and 23%〔95%CI(16%,30%)〕for urban and rural areas,respectively,16%〔95%CI(14%,19%)〕and 24%〔95%CI(20%,28%)〕for those living with a spouse and without,respectively,and 13%〔95%CI(9%,17%)〕,12%〔95%CI(9%,15%)〕,17%〔95%CI(13%,20%)〕,26%〔95%CI(20%,31%)〕,33%〔95%CI(24%,42%)〕and 42%〔95%CI(22%,62%)〕for those at 60-64 years,65-69 years,70-74 years,75-79 years,80-84 years,85 and above,respectively.Besides this,MCI prevalence showed a trend of decrease with the increase of education level:30%〔95%CI(25%,35%)〕in those with little education(<1 year of education),while 10%〔95%CI(7%,13%)〕in those with university education(>12 years of education).Spatial distribution trend:prevalence varied significantly between provinces(autonomous regions/municipalities)(15%-37%)and between northern,northwestern,eastern,south-central,southwestern parts of China(17%-22%).Temporal distribution trend:the prevalence showed an increasing trend in the last decade(11%-28%).Conclusion The prevalence of MCI in Chinese elderly population showed an increasing trend from January 2010 to December 2020,with differences across provinces(autonomous regions/municipalities)and 5 geographical regions.In addition,the prevalence was higher in the female,less educated,older,rural,and spouseless groups.