间歇性禁食对心血管疾病危险因素影响的研究进展

近年来，我国心血管疾病的患病率和死亡率呈明显上升趋势，心血管疾病已成为危害我国居民健康的主要疾病。间歇性禁食（IF）作为一种周期性能量限制的饮食干预方式，已被证明有广泛的健康益处，有助于减轻体质量、改善葡萄糖调节、降低血压和血脂水平、抑制炎性反应等，进而延缓心血管疾病的发生与发展。目前，我国学者对IF在防治心血管疾病中的潜在作用关注不足。本文通过对IF对血脂异常、肥胖、糖尿病、高血压等心血管疾病危险因素的影响及其机制进行综述，旨在为心血管疾病的防治提供新思路。本研究发现IF在心血管疾病防治中具有潜在的应用前景，可用于防控心血管疾病发生的危险因素，其介导的代谢益处可能与激发"代谢转换"、增强白色脂肪褐变、促进自噬及重塑肠道菌群等有关。

Research Progress on the Influence of Intermittent Fasting on Cardiovascular Disease Risk Factors

In recent years,the prevalence and mortality of cardiovascular diseases in China have shown a significant upward trend,cardiovascular disease has become a major disease endangering the health of Chinese residents.Intermittent fasting(IF)as a cyclical energy restriction dietary intervention has been proven to have a wide range of health benefits,which can reduce weight,improve glucose regulation,lower blood pressure and blood lipid levels,inhibit inflammation,so as to delay the occurrence and development of cardiovascular disease.Currently,researchers in China have paid insufficient attention to the potential role of IF in the prevention and treatment of cardiovascular diseases.This article reviews the effects and mechanisms of IF on cardiovascular disease risk factors such as dyslipidemia,obesity,diabetes and hypertension,in order to provide new ideas for the prevention and treatment of cardiovascular diseases.It is found that IF has potential application prospects in the prevention and treatment of cardiovascular diseases,which can be used to prevent and control the risk factors of cardiovascular disease,the IFmediated metabolic benefits can be related to glucose-ketone body metabolic transformation,browning of white fat,autophagy pathway and remodeling of intestinal flora.