呼出气冷凝液生物标志物检测在呼吸系统疾病中的应用现状及前景

呼吸系统疾病越发受到人们广泛关注，其复杂多变的病征给医疗领域带来一系列挑战，许多临床常用的检查方法已不足以应对该局面，临床亟需更加方便快捷的检查方法为诊疗提供准确有效的依据。呼出气冷凝液（EBC）是以无创方式获得的呼吸道内衬液，是呼吸系统疾病生物标志物的一种新的重要来源，具有较高的临床研究价值。基于EBC的生物标志物检测方法，能有效反映患者病情变化，优化治疗方案。该方法以其操作简单、安全无创、重复性高、依从性好等优点，日益受到临床重视。本文系统分析了EBC中生物标志物检测方法在呼吸系统疾病中的诊断、监测、疗效评价及预后中的应用现状，并对其收集、检测规范及临床应用等提出相应问题，为其在临床上广泛应用提供有力依据。

Application of Biomarker Detection of Exhaled Air Condensate in Respiratory Diseases

Respiratory diseases are getting more and more attention,and their complex and changeable symptoms have brought a series of challenges to medical treatment.Many common clinical examination methods are not enough to comprehensively deal with the situation,and clinical examination methods are urgently needed to provide accurate and effective basis for diagnosis and treatment.The exhaled breath condensate(EBC)is a respiratory tract lining fluid obtained non-invasively,which is a new important source of biomarkers for respiratory diseases with high clinical research value.The EBC-based biomarker detection method can effectively reflect the changes in the patient's condition and optimize the treatment schedule.This method has received increasing clinical attention due to its advantages of simple operation,safety,non-invasiveness,high reproducibility,and good compliance.This article systematically analyzed the application status of biomarkers in EBC in the diagnosis,monitoring,efficacy evaluation and prognosis of respiratory diseases,and proposes corresponding problems in its collections,detection specifications and clinical applications,and provide a strong basis for its wide clinical application.