血小板参数、凝血功能指标与老年高血压患者发生体位性高血压的关系研究

背景 体位性高血压会增加中老年人群心血管疾病发生风险,而血小板参数与凝血功能指标是评估高血压患者缺血性心脑血管疾病发生风险的重要指标,故分析体位性高血压患者血小板参数和凝血功能指标变化有利于体位性高血压的诊治.目的 探究血小板参数、凝血功能指标与老年高血压患者发生体位性高血压的关系.方法 选取2020年9月至2021年...

Relationship of Platelet Parameters and Coagulation Function Indicators with Postural Hypertension in Elderly Patients with Hypertensive

Background Postural hypertension will increase the risk of cardiovascular disease in middleaged and elderly people.Platelet parameters and coagulation function indicators are important indicators to assess the risk of ischemic cardiovascular and cerebrovascular diseases in patients with hypertension.Analyzing changes of platelet parameters and coagulation function indicators in patients with postural hypertension is conducive to clinical diagnosis and treatment of postural hypertension.Objective To explore the relationship of platelet parameters and coagulation function indicators with postural hypertension in elderly patients with hypertensive.Methods A total of 243 elderly patients with hypertension treated in Aerospace Center Hospital from September 2020 to April 2021 were selected,including 107 patients with postural hypertension(postural hypertension group)and 136 patients without postural hypertension(control group).The clinical data and laboratory indexes were compared between the two groups.The influencing factors of postural hypertension in elderly patients with hypertension were analyzed by multivariate Logistic regression analysis;Pearson correlation analysis was used to analyze the correlation between ratio of aldosterone to rennin(ARR)in standing position and platelet parameters,coagulation function indicators in elderly patients with hypertension.Results The incidence of coronary heart disease and the proportion of patients with smoking history,drinking history and family history of hypertension in postural hypertension group were higher than those in the control group(P<0.05).The serum creatinine,ARR in lying position,ARR in standing position,platelet count(PLT),platelet distribution width(PDW),fibrinogen(FIB)in postural hypertension group were higher than those in the control group,the estimated glomerular filtration rate(eGFR)was lower than that in the control group,the average platelet volume(MPV)was greater than that in the control group,and the prothrombin time(PT),activated partial thromboplastin time(APTT)and thrombin time(TT)in the postural hypertension were shorter than those in the control group(P<0.05).Multivariate Logistic regression analysis showed that serum creatinineOR=1.135,95%CI(1.033,1.247)],eGFROR=1.262,95%CI(1.056,1.509)],ARR in standing positionOR=1.251,95%CI(1.051,1.489)],PLTOR=1.642,95%CI(1.059,2.547)],MPVOR=1.038,95%CI(1.004,1.073)],PDWOR=1.528,95%CI(1.061,2.200)],PTOR=1.248,95%CI(1.035,1.503)]and APTTOR=1.116,95%CI(1.048,1.189)]were independent influencing factors of postural hypertension in elderly patients with hypertension(P<0.05).Pearson correlation analysis showed that the ARR in standing position in elderly patients with hypertension was positively correlated with PLT(r=0.359),MPV(r=0.336),PDW(r=0.314)and FIB(r=0.263),and negatively correlated with PT(r=-0.327),APTT(r=-0.285)and TT(r=-0.345)(P<0.05).Conclusion PLT,MPV,PDW,PT and APTT are the influencing factors of postural hypertension in elderly patients with hypertension,while ARR in standing position is related to platelet parameters and coagulation function indicators in elderly patients with hypertension.