成人支气管哮喘患者血清25-羟维生素D水平与肺通气功能、最小诱发累积剂量的相关性研究

背景 维生素D(VitD)是一种有效的免疫调节剂,其缺乏与支气管哮喘(以下简称哮喘)患者气道炎症、病情加重和预后不良有关.目前,成人哮喘与VitD相关性的研究报道较少,且研究结果并不一致.目的 探讨成人哮喘患者血清25-羟维生素D〔25(OH)D〕水平与肺通气功能、最小诱发累积剂量(Dmin)的相关性.方法 本研究为回...

Correlation of Serum 25(OH)D Level with Pulmonary Ventilation Function and Minimum Induced Cumulative Dose in Adult Patients with Bronchial Asthma

Background Vitamin D(VitD)is an effective immunomodulator.Its deficiency is related to airway inflammation,aggravation and poor prognosis in patients with bronchial asthma(hereinafter referred to as asthma).At present,there are few reports on the correlation between adult asthma and VitD,and the research results are inconsistent.Objective To analyze the correlation of serum 25-hydroxyvitamin D[25(OH)D]level with pulmonary ventilation function and minimum induced cumulative dose(Dmin)in adult patients with asthma.Methods This study was a retrospective study.A total of 179 newly diagnosed asthma patients treated in the First Affiliated Hospital of Xinjiang Medical University from January 2020 to September 2021 were selected as the observation group,and 151 healthy people who underwent physical examination in the First Affiliated Hospital of Xinjiang Medical University in the same period were selected as the control group.The serum 25(OH)D level of the two groups was compared,the pulmonary ventilation function indexes[forced vital capacity(FVC),percentage of FVC in the predicted value,forced expiratory volume in one second(FEV₁),percentage of FEV₁ in the predicted value,FEV₁/FVC,percentage of FEV₁/FVC in the predicted value,peak expiratory flow(PEF),percentage of PEF in the predicted value,and percentage of forced expiratory flow at 25%of FVC exhaled(FEF₂₅),forced expiratory flow at 50%of FVC exhaled(FEF₅₀),forced expiratory flow at 75%of FVC exhaled(FEF₇₅),maximal mid-expiratory flow(MMEF)in the predicted value]and Dmin were compared in asthma patients with different serum 25(OH)D levels.The correlation between serum 25(OH)D level and Dmin in adult patients with asthma was analyzed by Pearson correlation analysis.Results The serum 25(OH)D level in the observation group was lower than that in the control group(P<0.05).There was no significant difference in FVC,percentage of FVC in the predicted value,FEV₁,percentage of FEV₁ in the predicted value,FEV₁/FVC,percentage of FEV₁/FVC in the predicted value,PEF,percentage of PEF in the predicted value,and percentage of FEF₂₅,FEF₅₀,FEF₇₅,MMEF in the predicted value in asthma patients with different serum 25(OH)D levels(P>0.05).The Dmin of asthma patients with insufficient and deficient serum 25(OH)D level was lower than that of asthma patients with normal serum 25(OH)D level,and the Dmin of asthma patients with insufficient serum 25(OH)D level was lower than that of asthma patients with insufficient serum 25(OH)D level(P<0.05).Pearson correlation analysis showed that,the serum 25(OH)D level in adult patients with asthma was positively correlated with the Dmin(r=0.300,P<0.001).Conclusion Serum 25(OH)D level is not related to pulmonary ventilation function in adult patients with asthma,but is positively correlated with the Dmin.Therefore,serum 25(OH)D level has a certain reference value for evaluating airway hyperresponsiveness in adult patients with asthma.