系统性免疫炎症指数与高血压患者发生抑郁症的关系研究

背景 抑郁症在高血压患者中非常普遍,其已被证实与低度全身炎症有关.系统性免疫炎症指数(SII)是一种综合性的新型炎症指标,是评估全身炎症和免疫应答之间平衡状态的客观指标,与多种疾病相关.然而,SII与高血压患者发生抑郁症的相关性尚不明确.目的 探索SII与高血压患者发生抑郁症的关系.方法 选取2020年7月至2021年...

Relationship between Systemic Immune-inflammation Index and Depression in Patients with Hypertension

Background Depression is very common in patients with hypertension and has been shown to be associated with low-grade systemic inflammation.The systemic immune-inflammation index(SII)is a comprehensive novel inflammatory index,an objective marker to assess the balance between systemic inflammation and immune response,and is associated with a variety of diseases.However,the relationship between SII and depression in patients with hypertension is not clear.Objective To explore the relationship between SII and depression in patients with hypertension.Methods A total of 270 patients with hypertension hospitalized in the Internal Medicine-Cardiovascular Department of Affiliated Renhe Hospital of China Three Gorges University from July 2020 to April 2021 were selected as the research objects.The general data and laboratory examination indexes of patients were collected.According to the Hamilton Depression Scale(HAMD)score,the patients were divided into non-depression group(HAMD score<20 points,240 cases)and depression group(HAMD score≥20 points,30 cases).According to the SII quartile,the patients were divided into Q1 group(SII≤330.60,72 cases),Q2 group(SII was 330.61-426.43,68 cases),Q3 group(SII was 426.44-695.64,68 cases),Q4 group(SII>695.64,62 cases).Multivariate Logistic regression analysis was used to explore the influencing factors of depression in patients with hypertension.Results The proportion of patients with coronary heart disease and SII in the depression group were higher than those in the non-depression group,and the number of drugs taken was more than that in the non-depression group(P<0.05).The results of multivariate Logistic regression analysis showed that SII>695.64 was a risk factor of depression in hypertensive patients[OR=4.803,95%CI(1.443,15.980),P<0.05].The incidence of depression increased with the increase of SII in patients with hypertension(P<0.05).Conclusion SII>695.64 is a risk factor for depression in patients with hypertension,and the risk of depression increases with the increase of SII.