国产奥美拉唑治疗消化性溃疡的疗效研究

目的研究国产奥美拉唑对消化性溃疡的疗效。方法对112例经内镜确诊的消化性溃疡患者随机分为两组,其中试验组80例,对照组32例,分别予以奥美拉唑及进口洛赛克口服,试验组第一周每日2次,每次20mg,第二～四周,每日1次,每次20mg,十二指肠溃疡一疗程为28d,胃溃疡一疗程为56d,对照组服用方法,剂量和疗程同试验组,两组在治疗过程均予使用抗幽门螺杆菌感染药物2周。结果试验组溃疡愈合率为58.75%,显效率为27.5%,总有效率86.25%;对照组溃疡愈合率59.38%。显效率为31.25%,总有效率为90.63%,两组在治疗消化性溃疡有效率方面均差异无统计学意义(P>0.05)。结论国产奥美拉唑是治疗消化性溃疡的有效药物。

Therapeutic observation of domestic omeprazole in the treatment of peptic ulcer

OBJECTIVE To study the efficacy of domestic omeprazole in the treatment of peptic ulcer.METHODS 112 patients of peptic ulcer assessed by endoscopy were randomly divided into two groups-observation group and control group.80 patients in observation group were treated with domestic omeprazole 20mg bid p.o.for the first week and for the rest day qd duodenal ulcer was treatal for 28d.gastric ulcer was treated for 56d.32 patients in control group received imported omeprazole its dose,way and course were consistent with observation group.At the same time each patients in two group additionally took anti-Helicobacter pylori drugs for two week.RESULTS The cured,marked and total effective rate of observation group were 58.75%,27.50% and 86.25%,and that of cntrol group were 59.38%,31.25% and 90.63% respectively.There was no significant difference in the total effective rate between two groups(P>0.05).CONCLUSION Domestic omeprazole and imported omeprazole possess same therapeutic effect in the treatment of peptic ulcer.