| 兔膝骨关节炎软骨细胞凋亡调控基因的研究 |
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| 引用本文： | 李志,郭志强,张晓刚.兔膝骨关节炎软骨细胞凋亡调控基因的研究[J].中国中医骨伤科杂志,2006(Z1). |
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| 作者姓名： | 李志 郭志强 张晓刚 |
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| 作者单位： | [1]甘肃中医学院 [2]兰州大学附属天浩医院 [3]甘肃中医学院 兰州 |
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| 摘 要： | 目的:观察凋亡调控基因bcl-2在骨关节炎(OA)关节软骨中的表达,试图探讨bcl-2在OA发病中的作用机制。方法:参照Hulth的造模方法于无菌条件下,以健康青紫兰家兔左侧膝关节制作OA动物模型,并以右侧膝关节作为正常对照,应用免疫组织化学方法对第8周兔膝关节软骨中bcl-2进行检测。结果:OA组关节软骨bcl-2的阳性表达强度显著高于正常组,主要分布于关节软骨的浅层和中层,但OA组关节软骨深层胶原化区中bcl-2表达无明显变化。结论:OA组关节软骨细胞凋亡调控基因bcl-2表达较正常对照组明显增强,因此bcl-2的调节作用可能是OA病理过程进展缓慢的一个重要原因。
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| 关 键 词： | 骨关节炎 软骨细胞 凋亡 |
Control genes of chondrocyte apoptosis in rabbits' knee osteoarthritis |
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| Li Zhi,Guo Zhiqing,Zhang Xiaogang Gansu College of Tradicional Chinese Medicine,Gansu,Lanzhou ..Control genes of chondrocyte apoptosis in rabbits' knee osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2006(Z1). |
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| Authors: | Li Zhi Guo Zhiqing Zhang Xiaogang Gansu College of Tradicional Chinese Medicine Gansu Lanzhou |
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| Institution: | Li Zhi,Guo Zhiqing,Zhang Xiaogang Gansu College of Tradicional Chinese Medicine,Gansu,Lanzhou 730000. |
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| Abstract: | Objective:To observe the expression of bcl-2 in ostcoarthrisis(OA) and try to investigate the bcl-2 mechanism of action in OA. Methods:By Hulth method,the healthy chinchiila rabbits' left knees were made for OA model under asepsis condition and the right knees as normal subjects. The expression of bcl-2 in the articular cartilage was determined by mmunohistochemical techniques at the time of 8 weeks. Results: The strength of bcl-2 positive chondrocytes in articular cartilage of OA group was evidently high than that of the normal, which mainly located in the superficial and middle zone. but deeply collagenous zone in OA group without significant change. Conclusions: The expressions of bcl-2 positive chondrocytes in articular cartilage with OA were significantly strength. So the function of bcl-2 is a possible reason of OA chronic pathologic process. |
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| Keywords: | Osteoarthritis Chondrocytes Apoptosis |
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