福州市区1991-2005年女性乳腺癌发病趋势分析

目的分析1991-2005年福州市区女性乳腺癌发病趋势,为制定防治措施提供科学依据。方法从福建省肿瘤防治办公室获取女性乳腺癌的病例资料,根据人口普查资料中性别、年龄构成推算各年份分性别、年龄组人口数,计算粗发病率、世界人口标化发病率和各年龄组发病率,采用对数线性回归法计算发病率的年度变化百分比（APC）,并用病例数进行加权计算。结果 1991-2005年福州市区共有2 812例女性乳腺癌新发病例。发病呈现明显的上升趋势,标化发病率从1991-1992年的18.44/10万上升至2003-2005年的32.64/10万,上升了77.01%,年变化百分率为5.369%（P=0.001）。45～54岁、55～64岁和65～74岁3个年龄段的发病率增长趋势显著,APC分别为4.873%、6.423%和9.512%（P〈0.05）。结论福州市区女性乳腺癌的发病率呈明显的上升趋势,应加强乳腺癌防治,提倡健康的生活方式和合理饮食结构。

Incidence trend of female breast cancer in Fuzhou city,1991-2005

Objective To explore the incidence trend of female breast cancer in Fuzhou city during 1991-2005,and to provide scientific basis for breast cancer prevention and control.Methods The data were obtained from the Cancer Prevention and Treatment Office of Fujian Province.The crude incidence rate,age-adjusted rate of the world standard population and age-specific incidence rate were calculated.Annual percentage changes（APC） in incidence were estimated by means of a log-linear regression and weighted by the number of cases.Results During 1991-2005,2 812 female breast cancer patients were registered.The age-adjusted incidence rate increased by 77.01%（from 18.44/100 000 during 1991-1992 to 32.64/100 000 during 2003-2005）.The APC was 5.369%（P=0.001）.Significant increases in age-specific incidence rates were found in age groups of 45-54,55-64 and 65-74,with the APC of 4.837%,6.423% and 9.512%,respectively.Conclusion Incidence rate of female breast cancer increased significantly in Fuzhou city during 1991-2005.Prevention and treatment of breast cancer should be strengthened and healthy lifestyle and dietary pattern should be advocated.