| 血清淀粉样蛋白A在鼻息肉组织中的表达 |
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| 引用本文： | 丁明虹,刘文龙,郭洁波,徐睿,夏文彤,史剑波,李华斌. 血清淀粉样蛋白A在鼻息肉组织中的表达[J]. 中国耳鼻咽喉头颈外科, 2012, 0(2): 89-91 |
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| 作者姓名： | 丁明虹 刘文龙 郭洁波 徐睿 夏文彤 史剑波 李华斌 |
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| 作者单位： | 中山大学附属第一医院耳鼻喉科医院;粤北人民医院耳鼻咽喉科 |
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| 基金项目： | 国家自然科学基金面上项目(81070771、81070772);广东省自然科学基金项目(S2011010004634、S2011020002295);教育部新世纪优秀人才支持计划(NCET-10-0851)联合资助 |
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| 摘 要： | 目的探讨血清淀粉样蛋白A（serumamyloid A,SAA）在鼻息肉组织中的表达情况。方法 15例鼻息肉患者和9例正常对照者,分别采用免疫组化（immunohistochemistry,IHC）、定量逆转录聚合酶链反应（quantitative reverse transcription polymerase chainreaction,qRT-PCR）和酶联免疫吸附试验（ELISA）检测鼻息肉和对照鼻甲组织中SAA的定位、mRNA及蛋白表达情况。结果鼻息肉组织中SAA呈现广泛的阳性染色,而对照组织仅有轻微阳性染色。鼻息肉SAA mRNA相对含量和蛋白浓度比对照组织中增高,差异均有显著性意义（P〈0.05）。鼻息肉SAA表达与鼻息肉大小相关。结论 SAA在鼻息肉表达增高提示SAA可能参与了鼻息肉的发病过程。
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| 关 键 词： | 血清淀粉样蛋白A 细胞因子类 鼻息肉 |
Elevated expression of serum amyloid A in nasal polyps |
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| DING Minghong,LIU Wenlong,GUO Jiebo,XU Rut,XIA Wentong,SHI Jianbo,LI Huabin. Elevated expression of serum amyloid A in nasal polyps[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2012, 0(2): 89-91 |
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| Authors: | DING Minghong LIU Wenlong GUO Jiebo XU Rut XIA Wentong SHI Jianbo LI Huabin |
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| Affiliation: | 1 (1 Otolaryngology Hospital,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou,Guangdong,510080, China;2 Department of Otolaryngology,Yue Bei People’s Hospital,Shaoguan,Guangdong,512026,China) |
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| Abstract: | OBJECTIVE To study the expression of serum amyloid A(SAA) in nasal polyps(NP). METHODS Fifteen Chinese adult NP patients were enrolled in this study.The level of SAA in polyp tissues was examined by using immunohistochemistry staining method,quantitative reverse transcription polymerase chain reaction(qRT-PCR) and enzyme-linked immunosorbent assay(ELISA).RESULTS The SAA mRNA and protein level were significantly overexpressed in polyp tissues compared with that in control tissues (P<0.05).SAA level was significantly associated with NP severity.CONCLUSION The result suggested that SAA may play a role in the pathogenesis of NP. |
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| Keywords: | Serum Amyloid A Protein Cytokines Nanal Polyps |
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