丙戊酸钠血药浓度监测及其治疗儿童癫痫224例疗效分析

目的:为合理使用丙戊酸钠治疗儿童癫痫提供参考。方法:采用荧光偏振免疫分析法(FPIA)测定224例癫痫患儿血清丙戊酸浓度。结果:丙戊酸钠血药浓度<50、50～100、>100 mg/L的病例数及比例分别为43例(26.22%)、106例(64.64%)和15例(9.15%),控制癫痫发作的显效率分别为37.21%、78.30%和53.33%。结论:卡马西平和苯巴比妥可使丙戊酸钠的血药浓度降低。血清丙戊酸钠浓度与剂量相关性差,个体差异大,临床上在使用丙戊酸钠治疗癫痫患儿时,应监测血药浓度并实行个体化给药。

The Analysis of Serum Concentrations of Valproic Acid of 224 Epileptic Children

Objective: To provide some information about rationally administrating valproic acid for epileptic children.Methods: The serum concentrations of valproate sodium of 224 children with epilepsy were monitored by fluorescence polarization immunoassay(FPIA).Results: The concentrations of sodium valproate which were <50 mg/L,50~100 mg/L,>100 mg/L accounted for 43 cases(26.22%),106 cases(64.64%),15 cases(9.15%) and the total effective rates were 37.21%,78.30%,53.33%.The combination medication of carbamazepine and phenobarbital could decrease the serum concentration of valproic acid.Conclusions: Monitoring of serum concentration of valproic acid is of great importance in rationally administrating valproic acid for epileptic children,and the individual difference of serum concentration is large.It is suggested that an individual administrated scheme should be applied in clinical practice.