Na+/H+ countertransport and calcium exchange in peripheral blood cells of healthy subjects and patients with chronic heart failure |
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| Authors: | A. B. Gadzhiev V. G. Naumov A. A. Kubatiev Yu. N. Belenkov |
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| Affiliation: | (1) A. L. Myasnikov Institute of Cardiology, Cardiology Research Center, Russian Academy of Medical Sciences, Moscow;(2) Department of General Pathology and Pathophysiology, Russian Medical Academy of Postgraduate Education, Moscow |
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| Abstract: | A comparative study is performed of Na+/H+ exchange and Ca2− mobilization in erythrocytes and platelets of patients with stage I–II chronic heart failure caused by dilative cardiomyopathy and ischemic heart disease. A significant rise in the Na+/H+ exchange rate is found in the cells of chronic heart failure patients, which correlates with an elevated erythrocyte and platelet concentration of Ca2+ and an increased “calcium” response of platelets to inductors. The findings testify to a certain functional relationship between various cation-transporting cellular systems whose change in properties upon chronic heart failure can play an important pathogenic role. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N o 12, pp. 572–575, December, 1994 |
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| Keywords: | Na +/H+ exchange Ca 2+ exchange chronic heart failure |
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