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Small CD4+8+TCRlow thymocytes contain precursors of mature T cells
Authors:Wojciech Swat  Harald Von Boehmer  Pawel Kisielow
Abstract:To evaluate directly the developmental potential of cortical CD4+8+ thymocytes, highly purified populations of small, nondividing CD4+8+TCRlow and large, dividing CD4+8+TCRhigh thymocytes from H-2d mice expressing a transgenic T cell receptor restricted by H-2Db (major histocompatibility complex class I) molecules were transferred into the thymus of normal, nonirradiated H-2b recipient mice. The results show that both populations generate CD4?8+ thymocytes under these conditions, thus providing conclusive evidence that small cortical thymocytes do not represent a “dead end” but an important intermediate stage in T cell development.
Keywords:Positive selection  T cell precursors  Cortical thymocytes
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