| Persistent occult hepatitis B virus infection： Experimental findings and clinical implications |
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| 作者姓名： | Mulrooney-Cousins PM Michalak TI |
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| 作者单位： | Molecular Virology and Hepatology Research Division of BioMedical Science Faculty of Medicine Health Sciences Centre Memorial University St. John's NL A1B 3V6 Canada,Molecular Virology and Hepatology Research Division of BioMedical Science Faculty of Medicine Health Sciences Centre Memorial University St. John's NL A1B 3V6 Canada |
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| 基金项目： | operating research grants from the Canadian Institutes of Health Research, Canada and the Canada Research Chair Program, and the Canada Foundation for Innovation |
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| 摘 要： | Hepatitis B virus （HBV） is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic, serologically evident infection, occult persistent HBV carriage has been identified since nucleic acid amplification assays of enhanced sensitivity became introduced for detection of hepadnaviral genomes and their replicative intermediates. Current evidence indicates that occult HBV infection is a common and long-term consequence of resolution of acute hepatitis B. This form of residual infection is termed as secondary occult infection （SOI）. The data from the woodchuck model of HBV infection indicate that exposure to small amounts of hepadnavirus can also cause primary occult infection （POI） where virus genome, but no serological makers of exposure to virus, are detectable, and the liver may not be involved. However, virus replicates at low levels in the lymphatic system in both these forms. We briefly summarize the current understanding of the nature and characteristics of occult hepadnaviral persistence as well as of its documented and expected pathological consequences.
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| 关 键 词： | 乙肝 肝炎病毒 滤过性毒菌 感染 |
| 收稿时间： | 2007 Jul 24 |
Persistent occult hepatitis B virus infection: experimental findings and clinical implications |
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| Mulrooney-Cousins PM,Michalak TI.Persistent occult hepatitis B virus infection: experimental findings and clinical implications[J].World Journal of Gastroenterology,2007,13(43):5682-5686. |
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| Authors: | Mulrooney-Cousins Patricia M Michalak Tomasz I |
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| Institution: | Patricia M Mulrooney-Cousins(Molecular Virology and Hepatology Research, Division of BioMedical Science, Faculty of Medicine, Health Sciences Centre, Memorial University, St. John's, NL Al B 3V6, Canada);Tomasz I Michalak(Molecular Virology and Hepatology Research, Division of BioMedical Science, Faculty of Medicine, Health Sciences Centre, Memorial University, St. John's, NL Al B 3V6, Canada); |
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| Abstract: | Hepatitis B virus (HBV) is a highly pathogenic virus that causes chronic liver diseases in millions of people globally. In addition to a symptomatic, serologically evident infection, occult persistent HBV carriage has been identified since nucleic acid amplification assays of enhanced sensitivity became introduced for detection of hepadnaviral genomes and their replicative intermediates. Current evidence indicates that occult HBV infection is a common and long-term consequence of resolution of acute hepatitis B. This form of residual infection is termed as secondary occult infection (SOI). The data from the woodchuck model of HBV infection indicate that exposure to small amounts of hepadnavirus can also cause primary occult infection (POI) where virus genome, but no serological makers of exposure to virus, are detectable, and the liver may not be involved. However, virus replicates at low levels in the lymphatic system in both these forms. We briefly summarize the current understanding of the nature and characteristics of occult hepadnaviral persistence as well as of its documented and expected pathological consequences. |
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| Keywords: | Hepatitis B virus Hepadnaviruses Woodchuck hepatitis virus Hepadnaviral hepatitis Occult viral persistence Hepadnavirus lymphotropism Primary occult infection Secondary occult infection Virus reactivation |
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