2型糖尿病动物模型的研究进展

目的：综述近年来2型糖尿病动物模型的几种建立方法。方法：主要对2型糖尿病动物模型建立的方法与技术进行综述和评价。结果：2型糖尿病动物模型主要可分为自发性2型糖尿病动物模型、实验性2型糖尿病动物模型、基因敲除复制2型糖尿病模型和胰岛素抵抗的细胞模型等四种。结论：上述四种动物模型的建立方法各有优缺点，实验性2型糖尿病动物模型价格低廉，可操作性强，并且在一定程度上符合人类糖尿病形成的病理过程，成为目前研究2型糖尿病的最主要动物模型。

Advances in the Animal Models for Non-insulin-dependent Diabetes Mellitus

Objective:To introduce Some establishing methods to Non-insulin-dependent diabetes mellitus(NIDDM) animal model.Methods:The established methods and techniques for the NIDDM animal model are summarized.Results:The NIDDM animal model's establishing methods can meanly be divided into four aspects:spontaneous NIDDM model, experimental NIDDM model, gene knock-out NIDDM model and anti-insulin cell model for NIDDM.Conclusion:There are advantages and disadvantages in the four aspects to establish the NIDDM animal model.The experimental NIDDM model becomes the most important and commonly used animal model to research NIDDM due to the low-cost, better maneuverability and the similar pathological process with that of human being.