| 高效液相色谱-电喷雾离子阱质谱法初步鉴定复方酸枣仁汤中化学物质及血浆吸收成分 |
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| 引用本文： | 高博彦,孔令义.高效液相色谱-电喷雾离子阱质谱法初步鉴定复方酸枣仁汤中化学物质及血浆吸收成分[J].药学与临床研究,2010,18(3):250-252. |
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| 作者姓名： | 高博彦 孔令义 |
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| 作者单位： | 中国药科大学天然药物化学教研室,南京,210009 |
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| 基金项目： | "重大新药创制"科技重大专项项目 |
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| 摘 要： | 应用高效液相色谱-电喷雾离子阱质谱法鉴定了复方酸枣仁汤中的化学成分.实验采用Zorbax-C18色谱柱,二元线性梯度洗脱进行色谱分离,并与电喷雾离子阱质谱联用,根据负离子模式下的分子量与裂解规律,通过与文献及部分对照品的比对,推测化合物可能的结构.首次建立了高效液相色谱-电喷雾离子阱质谱法测定酸枣仁汤中化学成分及其在大鼠血浆中的吸收代谢成分,对进一步研究复方酸枣仁汤有较重要的意义.
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| 关 键 词： | 高效液相色谱-电喷雾离子阱质谱联用技术 复方酸枣仁汤 吸收代谢成分 |
Identification of Chemical and Metalobic Components of Fufang Suan-Zao-Ren-Tang Decoction by High Performance Liquid Chromatography-Electro Spray Ion Trap Mass Spectrometry |
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| GAO Bo-Yan and KONG Ling-yi.Identification of Chemical and Metalobic Components of Fufang Suan-Zao-Ren-Tang Decoction by High Performance Liquid Chromatography-Electro Spray Ion Trap Mass Spectrometry[J].Pharmacertical and Clinical Research,2010,18(3):250-252. |
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| Authors: | GAO Bo-Yan and KONG Ling-yi |
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| Institution: | Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 21009, China;Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 21009, China |
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| Abstract: | Chemical components of Fufang Suan-Zao-Ren-Tang decoction and their metabolites in rats were identified by HPLC-ESI-MS. Samples were separated by a Zorbax C18 column using a binary gradient elution, and analyzed by HPLC-ESI-MS. The ions of compounds in ne |
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| Keywords: | High performance liquid chromatography-electro spray ion trap-mass spectrometry Suan-Zao-Ren-Tang decoction Chemical components Metabolites |
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