二苯乙烯苷对SAMP8小鼠学习记忆能力的改善作用

目的:探讨二苯乙烯苷(TSG)对老年痴呆模型SAMP8鼠学习记忆能力的影响。方法:6月龄SAMP8鼠50只,随机均分为SAMP8空白组,阳性药石杉碱甲对照组,高、中、低TSG组;6月龄SAMR1鼠10只为正常对照组。各组分别灌胃相应药物45d后,采用Morris水迷宫方法,以逃避潜伏期、原平台象限停留时间等指标观察其行为学改变。结果:SAMR1组和TSG组在试验中逃避潜伏期明显短于SAMP8空白组(P<0.05)。平台象限的停留时间和穿越原平台次数在探索试验中明显多于SAMP8空白组(P<0.05)。可视平台试验结果各组无差异。结论:TSG能提高SAMP8鼠的学习记忆能力。

TSG on Learning and Memory Abilities in Senescence Accelerated SAMP8 Mouse

Objective： To observe the effects of on learning and memory accelerated SAMP8 mouse. Methods： Fifty SAMP8 at the age of 6th month were randomized into 5 groups： SAMP8 untreated control group, huperzine A control group, low-, mid and highdose groups of TSG, with 10 mice in each group. Another ten 6th month old SAMR1 mice were assigned to normal control group. After medication for forty-five days, Morris water maze test was used to assess the learning and memory abilities in each group. Results： SAMR1 group escape latency is shorter than SAMP8 group significantly （P 〈 0. 05 ） , it shows that SAMP8 group show obvious learning memory disorders. TSG treated groups significantly increased the time and times of swim in original platform quadrant in spatial probe test （P 〈 0.05 ）, and significantly shortened the escape latency in reverse platform quadrant test than SAMP8 group. There was no significant difference among each group in visual platform Test. Conclusion： TSG could improve the learning and memory abilities in SAMP8 mice.