Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives. |
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| Authors: | M Gok?e D Dogruer M F Sahin |
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| Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey. gokcemk@ydho.com |
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| Abstract: | A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. |
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