Current status of liver transplantation |
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Authors: | Deirdre?Kelly Email author" target="_blank">Anupam?SibalEmail author |
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Institution: | (1) The Liver Unit, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham;(2) Indraprastha Apollo Hospital, Santa Vihar, 110044 New Delhi, India |
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Abstract: | Liver transplantation is accepted therapy for acute or chronic liver failure. Survival after LT has improved significantly
in developed countries and this has increased the awareness of this treatment modality in the developing world. Successful
LT in both children and adults have now been reported from India. Chronic liver failure secondary to cholestatic liver disease
in the most frequent indication for LT, with biliary with atresia as the single commonest cause. Innovative techniques such
as reduced size, splint, and living donor liver transplantation are being applied more often to decrease long waiting times
and reduce associated morbidity and mortality. Early postoperative complications include primary graft failure, venous thrombosis,
rejection, biliary complications and infections. Late complication includes CMV or EBV infections, side effects of immunosuppression,
post transplantation lymphoproliferative disease and late biliary strictures. Most children achieve good quality of life.
There are still many lessons to learn and there are future challenges such as the ever increasing problems of donor scarcity
and the search for potent but less toxic immunosuppressive agents. |
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Keywords: | Liver transplantation Acute liver failure Chronic liver failure |
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