Über potentielle Analgetika, 8. Mitt. Synthese und pharmakologische Testung 3-, 4- und 5-substituierter N-Arylanthranilsäuren

Potential Analgesics, VIII: Synthesis and Pharmacological Test of 3-, 4- and 5-Substituted N-Arylanthranilic Acids For the determination of structure-activity relationships substituted N-arylanthranilic acids were synthesized and tested for their antiinflammatory activity by means of the carrageenin induced paw edema of the rat. The structural requirements for antiinflammatory activity were investigated by determination of the distribution coefficients, by UV spectroscopic measurements and by x-ray structure analysis.