冠状动脉病变与代谢综合征及高敏C反应蛋白关系的探讨

目的 探讨冠状动脉病变与代谢综合征、血清高敏C反应蛋白（hs—CRP）水平之间的关系。方法 对2003年4月至2004年4月期间北京协和医院就诊的227例临床怀疑冠心病的患者进行冠状动脉造影,将其中冠状动脉狭窄大于50％的170例患者按照中国代谢综合征诊断标准分为代谢综合征组和非代谢综合征组。对两组同时进行hs—CRP水平的测定。两组的冠状动脉造影和hs—CRP结果进行组内及组间统计学分析。结果 不同hs—CRP水平下冠状动脉病变类型的比较表明,随着hs—CRP水平的升高,代谢综合征组的冠状动脉病变严重程度加重,差异有统计学意义,特别是在hs-CRP〉3．5μg／ml时,这种差异尤其明显。结论 hs—CRP可以作为预测代谢综合征合并冠状动脉粥样硬化性心脏病患者冠状动脉病变严重程度的预测指标。

Serum high-sensitivity C-reactive protein level in patients with coronary heart disease complicating with or without metabolic syndrome

OBJECTIVE: To observe the relationship between serum high-sensitivity C-reactive protein (hs-CRP) level and coronary artery lesion in patients with coronary heart disease (CHD) complicating with or without metabolic syndrome. METHODS: CHD was confirmed in 170 out of 227 patients who were admitted into Peking union hospital because of chest pain by coronary artery angiography (CAG). Metabolic syndrome was diagnosed in 79 out of 170 CHD patients (MS group) and the relationship between serum hs-CRP level and coronary lesion was compared to CHD patients without metabolic syndrome (non-MS group). RESULTS: The number of CHD patients who had type B and C coronary stenosis and the serum level of hs-CRP was significantly higher in MS group than those in non-MS group, especially in patients with the serum level of hs-CRP > 3.5 mmol/L. CONCLUSION: For CHD patients complicating metabolic syndrome, hs-CRP is a reliable marker to predict the severity of coronary artery lesion.