阿普唑仑可降低射频导管消融手术患者的住院费用

目的观察术前加用阿普唑仑对射频导管消融手术患者的心理状况及住院费用的影响。方法前瞻性、随机、双盲、安慰剂对照研究142例因阵发性室上性心动过速而择期行首次心内电生理检查或射频导管消融手术的患者,随机纳入安慰剂组（对照组,70例）或阿普唑仑组（治疗组,72例）。所有患者均于入组当晚开始每晚睡前服用阿普唑仑0．4mg或外形、性状类似于治疗药的安慰剂,至少3天后行射频导管消融治疗。所有患者均于术前24h内行中国版90项症状量表评价。结果二组之间年龄、性别、体重、烟酒嗜好、职业、文化程度、婚姻状况、家庭关系和医疗费用的支付方式（即是否有医疗保险）等方面以及二组间合并高血压和糖尿病的患者数差异均无统计学意义。与对照组相比,治疗组射频导管消融术前的患者躯体化（1．38±0．40比1．65±0．56,P〈0．01）、焦虑（1．50±0．39比1．69±0.50,P〈0．05）、恐怖（1．24±0.36比1．47±0.57,P〈0．01）、精神病性（1．24±0．34比1．35±0．30,P〈0．05）和总均分（1．36±0．35比1．49±0．37,P〈0．05）等项目评分均有明显下降,治疗组住院费用（32498±1170）元,明显低于对照组（32947±1096）元,P〈0．05。结论术前服用阿普唑仑可改善射频导管消融手术患者的心理状况并降低其住院费用。

Alprazolam use improves psychological status and reduces hospitalization costs in patients with paroxysmal supraventricular tachycardia underwent radiofrequency catheter ablation

OBJECTIVE: To evaluate the effect of alprazolam use on psychological status and hospitalization cost in patient with paroxysmal supraventricular tachycardia underwent electrophysiology studies or radiofrequency catheter ablation. METHODS: In this prospective, randomized, double-blind, placebo-controlled study, 142 inpatients [77 males, mean age (43.1 +/- 14.5) years] were randomly assigned to receive alprazolam (0.4 mg qd at 10PM for 3 days, n = 72) or placebo (n = 70) 3 days before scheduled electrophysiology studies or radiofrequency catheter ablation. All patients were examined by the Chinese version of Symptom Checklist-90 (SCL-90) at 24 hours before the procedure. RESULTS: Compared with the placebo group, the scores of somatization (1.38 +/- 0.40 vs. 1.65 +/- 0.56, P < 0.01), anxiety (1.50 +/- 0.39 vs. 1.69 +/- 0.50, P < 0.05), phobic anxiety (1.24 +/- 0.36 vs. 1.47 +/- 0.57, P < 0.01), psychotism constructs (1.24 +/- 0.34 vs. 1.35 +/- 0.30, P < 0.05) and global severity index (1.36 +/- 0.35 vs. 1.49 +/- 0.37, P < 0.05) were significantly decreased in alprazolam group. The hospitalization costs were also significantly lower in alprazolam group (32 498 +/- 1170) yuan compared to placebo group (32 947 +/- 1096) yuan, P < 0.05. CONCLUSION: The alprazolam use before electrophysiology studies and radiofrequency catheter ablation can improve the patients' psychological status and reduce the hospitalization costs.