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联合应用1H-MRS与MR动态增强成像诊断乳腺肿瘤
引用本文:周欣,张婷婷,胡国清.联合应用1H-MRS与MR动态增强成像诊断乳腺肿瘤[J].中国医学影像技术,2012,28(9):1669-1672.
作者姓名:周欣  张婷婷  胡国清
作者单位:1. 三峡大学第一临床学院宜昌市中心人民医院普外科,湖北宜昌,443003
2. 三峡大学人民医院宜昌市第一人民医院放射科,湖北宜昌,443000
3. 华中科技大学同济医学院附属同济医院肿瘤中心,湖北武汉,430030
摘    要:目的比较应用MR动态增强成像(DCE-MRI)与联合应用1 H-MRS及DCE-MRI对乳腺肿瘤的诊断价值。方法回顾性分析50例乳腺肿瘤患者的1 H-MRS及DCE-MRI表现,包括恶性肿瘤33例,良性肿瘤17例,并与病理及临床随诊结果进行对比。对所有患者分别行常规扫描、1 H-MRS扫描及注射对比剂后动态增强扫描,分析时间-信号曲线(TIC)类型和胆碱(Cho)峰的显示情况。结果以TIC类型判断肿瘤的良恶性,诊断的敏感度为100%(33/33),特异度为58.82%(10/17),准确率为66.00%(33/50);应用1 H-MRS联合DCE-MRI诊断的敏感度为100%(33/33),特异度为88.24%(15/17),准确率为96.00%(48/50),与单纯DCE-MRI诊断的特异度和准确率差异有统计学意义(P均<0.02)。结论 DCE-MRI诊断乳腺肿瘤的特异度和准确率较低。1 H-MRS与DCE-MRI联合应用可提高对乳腺肿瘤的诊断准确率。

关 键 词:乳腺肿瘤  磁共振波谱  磁共振成像
收稿时间:2012/4/16 0:00:00
修稿时间:2012/6/14 0:00:00

Diagnosis of breast tumors with 1H-MRS and dynamic contrast-enhanced magnetic resonance imaging
ZHOU Xin,ZHANG Ting-ting and HU Guo-qing.Diagnosis of breast tumors with 1H-MRS and dynamic contrast-enhanced magnetic resonance imaging[J].Chinese Journal of Medical Imaging Technology,2012,28(9):1669-1672.
Authors:ZHOU Xin  ZHANG Ting-ting and HU Guo-qing
Institution:Department of General Surgery, the First College of Clinical Medical Science, Three Gorges University & Yichang Central People's Hospital, Yichang 443003, China;Department of Radiology, the People's Hospital of Three Gorges University & the First People's Hospital of Yichang, Yichang 443000, China;Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Abstract:Objective To compare the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) alone and combined with 1H-MRS in diagnosis of breast tumors. Methods 1H-MRS and DCE-MRI of 50 patients with breast tumors including 33 malignant lesions and 17 benign lesions were retrospectively analyzed. The diagnostic results of 1H-MRS and DCE-MRI were compared with pathological and clinical follow-up results. All patients underwent pre-enhanced conventional scanning, 1H-MRS scanning and DCE-MR scanning after injection of contrast agent. The type of time-intensity curves (TIC) and display of choline (Cho) peak for all lesions were calculated. Results The diagnostic sensitivity, specificity and accuracy rate for TIC alone was 100% (33/33), 58.82% (10/17) and 66.00% (33/50), respectively, while was 100% (33/33), 88.24% (15/17) and 96.00% (48/50) respectively for combined application of 1H-MRS and DCE-MRI. There was statistical difference in diagnostic specificity and accuracy rate between the two methods (both P<0.02). Conclusion DCE-MRI has lower specificity and accuracy rate for diagnosis of breast tumors. Combination of 1H-MRS and DCE-MRI can improve the diagnostic accuracy rate of breast tumors.
Keywords:Breast neoplasms  Magnetic resonance spectroscopy  Magnetic resonance imaging
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