Immunohistochemical Expression of p16, p21, p27 and Cyclin D1 in Oral Nevi and Melanoma |
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| Authors: | Bruno Augusto Benevenuto de Andrade Jorge Esquiche León Román Carlos Wilson Delgado-Azañero Adalberto Mosqueda-Taylor Oslei Paes de Almeida |
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| Affiliation: | 1.Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School,University of Campinas (UNICAMP),Piracicaba,Brazil;2.Pathology Section,Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi,Guatemala City,Guatemala;3.Oral Pathology and Medicine Department,Universidad Peruana Cayetano Heredia,Lima,Peru;4.Department of Health Care,Universidad Autónoma Metropolitana,Xochimilco, Mexico City,Mexico |
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| Abstract: | The acquisition of abnormalities at G1/S is considered a crucial step in the genesis and progression of melanoma. The expression of cell cycle regulators has also been used in various neoplasms as an adjunct to diagnosis. The aim of this study was to compare the expression of p16, p21, p27 and cyclin D1 in oral nevi and melanomas. Expression of these cell cycle regulatory proteins was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas. p16 and p27 were highly expressed in intramucosal nevi, whereas p21 and cyclin D1 expression was higher in oral melanomas. The results indicate that p21 and cyclin D1 may be involved in the development of oral melanomas, and eventually they may be useful in the differential diagnoses of oral benign and malignant melanocytic lesions. |
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| Keywords: | Oral melanoma Oral nevi Immunohistochemistry Cell cycle |
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