妊高征患者治疗前后血清TNF-α、IL-6和IL-8检测的临床意义

目的：探讨了妊高征患者治疗前后血清TNF-α、IL-6和IL-8水平的变化及意义。方法：采用放射免疫分析对36例妊高征患者进行了血清TNF-α、IL-6和IL-8水平检测并与35名正常孕妇作比较。结果：在治疗前血清TNF-α、IL-6和IL-8水平非常显著地高于正常孕妇组（P〈0．01），经治疗后2周，血清TNF-α、IL-6和IL-8水平与正常孕妇组比较，无显著性差异（P〉0．05）。结论：炎性细胞因子TNF-α、IL-6和IL-8在妊高征的发病机理中具有重要的作用，有一定的临床价值。

Clinical Significance of Measurement of Changes of Serum TNF-α, IL-6 and IL-8 Centent After Treatment in Patients with Pregnancy Induced Hypertension (PIH)

Objective To explore the clinical significance of changes of serum TNF - α, IL - 6 and IL - 8 levels in patients with pregnancy induced hypertension. Methods Serum TNF -α, IL - 6 and IL - 8 levels were measured with RIA in 36 patients with pregnancy induced hypertension both before and after 2 weeks of treatment as well as in 35 controls. Rosults Before treatment, the serum TNF - α, IL - 6 and IL - 8 levels were significantly higher in patients with PIH than those in the controls （ P 〈 0.01 ）, after treatment two weeks, treatment the serum TNF -α, IL - 6 and IL - 8 levels in the patients were not much different from those in the controls （P 〉 0.05）. Conclusion The inflammatory cytokines such as TNF -α, IL- 6 and IL -8 may play important roles in the pathogcnesis of pregnancy induced hypertension.