环丙沙星序贯疗法预防妇科术后感染的疗效和成本-效果分析

目的 评价环丙沙星序贯疗法预防妇科术后感染的临床疗效和经济效果。方法 411例妇科术后患者随机分为2组,序贯组(A组)205例:采用环丙沙星400mg,iv gtt,qd,连用2d后改用环丙沙星片剂500mg,po,Bid,连用3~4d;对照组(B组)206例:采用环丙沙星400mg,iv gtt,qd,连用4~5d,分别进行疗效及成本效果分析。结果A、B两组手术切口的甲级愈合率分别为96.1％和98.5％,两组术后体温变化及不良反应无统计学差异;A组的成本效果比低于B组。结论 两组具有相似的临床疗效(P>0.05),但序贯疗法与单纯静脉输注治疗相比,显著降低了总医疗费用,具有药物经济学意义。

Efficacy and the Cost-effectiveness analysis of Sequential Therapy of Ciprofloxacin in Precaution of Infections After Gynecological Operation

jective To evaluate efficacy and the cost-effectiveness of sequential therapy of ciprofloxacin in precaution of infections after gynecological operation. Methods 411 patients after gynecological operation were randomly divided into 2 groups. In the sequential therapy group(group A) there were 205 patients who were treated with ciprofloxacin iv drip in a regimen of 400mg, qd, for 2d, then with oral tablet ciprofloxacin in dose of 500mg, bid, for 3~4d in sequence; and in the contral group(group B) there were 206 patients who were treated with single ciprofloxacin iv drip in a regimen of 400mg, qd, for 4~5d. Efficacy and the cost-effectiveness in 2 groups were conducted respectively. Results The first healing rates of incisions in group A and grounp B were 96. 1% and 98. 5% respectively. The changes of temperature and the ADRs are no statistical difference between 2 groups. The costeffectiveness ratio of group A was lower than that of group B. Conclusion Similar therapeutic effect was obtained in both groups, but the total medical expenditure was significantly reduced in sequential therapy group with pharmaco-economic significance.