MMP-9在乳腺癌转移中的相关表达及临床意义

MMP-9属于基质金属蛋白酶的一种,在乳腺癌的转移过程中起一定作用,不但能降解基底膜和肿瘤组织周边的细胞外基质,还能促进血管的生成,为肿瘤的生长、局部侵袭乃至远处转移创造了条件.目前相关研究显示,MMP-9的过表达可以明显加快乳腺癌淋巴结转移的发生.研究MMP-9的表达对乳腺癌的治疗和预后有一定的指导意义.

MMP-9 expression in breast cancer metastasis and its clinical significance

Matrix metallopmteinase 9(MMP-9) is one kind of matrix metalloproteinases and plays a role in the process of breast cancer metastasis. It can not only degrade the basement membrane and the extracellular matrix around tumor tissue but also promote angiogenesis, even create conditions for the growth of tumors, local invasion and distant metastasis. Current study shows that the over-expression of MMP-9 can significantly speed up the breast lymph node metastasis and the relevant research will provide guidance for clinical treatment and prognosis of breast cancer.