FIBRINOLYTIC ACTIVITY IN THE SYNOVIAL MEMBRANE OF OSTEOARTHRITIS |
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| Authors: | MATUCCI-CERINIC, M. LOMBARDI, A. LOTTI, T. PIGNONE, A. SENESI, C. BUZZI, R. AGLIETTI, P. PARTSCH, G. CAGNONI, M. |
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| Affiliation: | Istituto di Clinica Medica IV, Patologia Medica I, Università di Firenze Italy; Istituto di Clinica Dermosifilopatica, Università di Firenze Italy Prima Clinica Ortopedica, Università di Firenze Italy Ludwig Boltzmann Institute fur Rheumatologie und Balneologie Wien-Oberlaa, Austria |
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| Abstract: | The fibrinolytic activity (FA) has been studied on the synovialmembrane obtained from 16 patients with osteoarthritis (OA),20 patients with rheumatoid arthritis (RA) and 11 control subjects.Todd's autohistographic method, modified by Lotti, was usedto investigate the FA and the monoclonal antibodies againstu-PA and t-PA were used to identify the main plasminogen activator. Our results show that the FA is increased in the synovial membraneof patients with OA in comparison with the synovial FA of controlsubjects. In the synovial membranes from patients with RA, theFA shows different results: in some specimens FA is increased,and in others it is diminished or similar, compared with FAof samples from healthy controls. Thus, our data on synovialFA in OA confirm the previous reports, performed in vitro, onthe activation of the plasmin system in this degenerative disease.The activity of the fibrinolytic system seems to participatein the cartilage degeneration and, via the activation of collagenase,to perpetuate the cartilage damage. KEY WORDS: Fibrinolysis, Plasminogen activators, Osteoarthritis, Rheumatoid arthritis, Synovial membrane |
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