| 大鼠严重烧伤后心肌细胞膜损伤的实验研究 |
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| 引用本文： | 迟路湘,杨宗城,黎鳌.大鼠严重烧伤后心肌细胞膜损伤的实验研究[J].中华创伤杂志,1999,15(2):121-123. |
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| 作者姓名： | 迟路湘 杨宗城 黎鳌 |
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| 作者单位： | 1. 西南医院心内科
2. 400038,重庆,第三军医大学附属西南医院烧伤研究所 |
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| 基金项目： | 本课题为国家自然科学基金资助项目(No.39290700) |
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| 摘 要： | 目的 探讨严重烧伤后心肌细胞膜损伤后的机制及意义。方法 大鼠在体致伤模型，采用生化法，荧光偏振法分别测定伤后２４小时心肌细胞膜磷脂含量，膜脂流动性，膜酶活性及膜脂质过氧化的方法。结果 伤后１小时，膜酶活力降低；伤后３小时，心肌细胞膜磷脂含量减少，膜脂质过氧化加强；伤后６小时，膜荧光偏振度升高，流动性降低。
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| 关 键 词： | 烧伤 细胞膜 心肌损伤 实验研究 |
| 修稿时间： | 1998年2月9日 |
Experimental Study on Myocardial Cellular Membrane Injury After Severe Burn in Rats |
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| CHI Luxiang,YANG Zongcheng,Li Ao.Experimental Study on Myocardial Cellular Membrane Injury After Severe Burn in Rats[J].Chinese Journal of Traumatology,1999,15(2):121-123. |
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| Authors: | CHI Luxiang YANG Zongcheng Li Ao |
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| Abstract: | Objective To explore the mechanism and significance of myocardial cellularmembrane damage following severe burn injury in rats. Methods In the burned rat models invivo, the total membranous phospholipid contats, membranous enzyme, fluidity and lipidperoxidation in myocardium were oberved with biochemistry and the fluorarence polarizationtechnique. Results The membranous enzyme activity markedly decreased (P<0.01) at 1 hourafter burn. The total phospholipid contents decreatal (P<0.01) and membranous llpid peroXjdationwas enhanced at 3 hours after burn. The membranous fluldity obviously decrease (P<0.01) at6 hours after burn. ConclusioNs The serial changes in burned ratS, acting on each other asdescribed above, can result in the damage of myocardial cellular membrane structure andfunction, as well as the integrity of Cell membrane. |
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| Keywords: | Burns Cellular membrane myocardium |
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