碱性成纤维细胞生长因子促进周围神经功能恢复的研究

目的 探讨碱性成纤维细胞生长因子对受损伤的周围神经功能恢复的影响。方法 以钳夹损伤左侧坐骨神经大鼠为模型，治疗组肌肉注射ｂＦＧＦ，对照组注射等渗盐水，隔日１次。术后２，３，４周分别对治疗组和对照组损伤侧及健侧坐骨神经，腓肠肌进行功能检测，以健侧为１００％，求出损伤侧各指标的恢复率。

Study on Function Recovery of Peripheral Nerve Promoted by Basic Fibroblast Growth Factor

Objective To investigate the effect of basic fibroblast growth factor (bFGF) onthe function recovery of injured peripheral nerve. Methods The rats with the left scintic nervecrushed were cd as models. In the beted group, the rats were intramuscularly injected withbFGF, and in the control group, injected with normal saline, once every other day. Thefunction of the sciatic nerves of the rats in the two groups were measured respectively at two,three and four weeks postoperation . The the of recovery in each rat was calculated accordingto the normal (right) the which assumed as 100%. Results The rabid of recovery of amplitudeand conduedon vdlocity of nerve action potential in the treated group were higher than thatof the control group (P <0.05 and P <0.01). The rated of recovery of gustrocnemius muscleevoked action potential and single muscle twitch, and tetanhation were higher in the treatedgrOUP, too (P <0.05 and P <0.01). Conclusions It suggests that bFGF can prompt the functionalrecovery of the injured peripheral nerve.