小剂量米非司酮治疗子宫内膜异位症的临床研究

目的 探讨小剂量米非司酮对子宫内膜异位症的疗效。方法38例子宫内膜异位症患者,于月经周期第1天开始服用米非司酮10mg,每日1次,连续服用6个月观察临床疗效及生殖激素的改变。结果 服药期间所有患者均闭经,痛经及盆腔痛消失,腺肌症患者子宫明显缩小,卵巢异位囊肿缩小或消失。雌二醇(E2)及孕酮(P)处于早-中卵泡期水平。结论 小剂量米非司酮长期服用可破坏子宫内膜的完整性,干扰其功能,影响在位及异位内膜的生物学效应,从而起到治疗子宫内膜异位症的作用。尤其适用于围绝经期及术后复发的子宫内膜异位症的治疗。

Low Dose Mifeipristone Treatment of Endometriosis

Objective To study the effects of low dose mifelpristone on the treatment of endometriosis. Methods 38 patients with endometriosis were given mifelpristone 10mg per day within a period of 6 months. Clinical effects and the level of E2 and P were observed. Results Amenorrhea happened in all patients, pelvic pain disappeared. The uterine volume reduced. Ovary chocolate cysts reduced or disappeared. E2 and P were at lower level. Conclusions Mifelpristone has good effects on the treatment of endomeriosis,especially for the peri-menopausal women with endometriosis and for patients pre-operation and post-operation.