| 免疫系统的衰老及其机制 |
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| 引用本文： | 张娜,李电东,邓洪斌. 免疫系统的衰老及其机制[J]. 国外医学:老年医学分册, 2014, 0(1): 27-32 |
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| 作者姓名： | 张娜 李电东 邓洪斌 |
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| 作者单位： | 中国医学科学院北京协和医学院医药生物技术研究所,中国北京100050 |
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| 基金项目： | 国家自然科学基金资助项目（81170326） |
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| 摘 要： | 免疫系统随着年龄的增加而功能退化,出现免疫系统衰老.免疫系统衰老与老年人群感染的易感性、疫苗的低效性、自身免疫性疾病增加以及肿瘤多发性密切相关.免疫系统衰老的特征表现为细胞介导的免疫功能下降以及抗体介导的体液免疫应答的降低.在衰老过程中,T细胞和B细胞功能的下降与先天性免疫系统功能的降低同时存在.本文就免疫系统随年龄衰老的改变及其内在机制进行综述.
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| 关 键 词： | 衰老 先天性免疫 获得性免疫 |
The Aging of the Immune System and its Mechanisms |
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| Zhang Na,Li Diandong,Deng Hongbin. The Aging of the Immune System and its Mechanisms[J]. Foreign Medical Sciences(Geriatrics), 2014, 0(1): 27-32 |
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| Authors: | Zhang Na Li Diandong Deng Hongbin |
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| Affiliation: | ( Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China) |
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| Abstract: | An age - related decline in immune system contributes to the susceptibility of elderly persons to infectious diseases, vaccine failure, and possibly autoimmunity and cancer. The aging of the immune system is characterized by a decrease in cell - medi- ated immune function and the reduced humoral immune responses. Age - dependent defects in T - and B - cell function coexist with age - related changes within the innate immune system. In this review the mechanisms and consequences of age associated immune al- terations are discussed. |
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| Keywords: | Aging Innate immunity Adaptive immunity |
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