丙泊酚长链脂肪乳和中／长链脂肪乳注射液对肝脏能量代谢的影响

目的：观察丙泊酚长链脂肪乳注射液（LCT ）和丙泊酚中／长链脂肪乳注射液（MCT／LCT ）短时间恒速输注对肝脏能量代谢的影响。方法选择年龄为18～50岁，术前 ASA分级Ⅰ～Ⅱ级的20例择期手术病人，随机分为2组，每组10例，分别行丙泊酚长链脂肪乳注射液4 mg · kg-1· h-1维持麻醉（L组）、丙泊酚中／长链脂肪乳注射液4 mg · kg-1· h-1维持麻醉（M组）。在气管插管后（T1）、维持输注丙泊酚麻醉2 h后（T 2），各取静脉血检测乙酰乙酸、β-羟丁酸值，计算血酮体比率（乙酰乙酸／β-羟丁酸）。结果 T1、T2时点两组乙酰乙酸、β-羟丁酸和血酮体比率之间比较，差异均无统计学意义（P＞0．05）。结论丙泊酚长链脂肪乳注射液和丙泊酚中／长链脂肪乳注射液短时间持续输注对肝脏能量代谢没有明显的影响。

Effect of propofol long-chain fat emulsion injection and propofol medium/long-chain fat emulsion injection on hepatic energy metabolism

Objective To observe the effect of propofol long-chain fat emulsion injection （LCT ） and propofol medium /long-chain fat emulsion injection （MCT/LCT ） in short time infusion on hepatic energy metabolism .Methods Total of 20 patients aged 18~50 years with ASA ⅠorⅡ undergoing elec-tive surgery were randomized into 2 groups （n=10 for each） which were propofol long-chain fat emul-sion injection 4 mg · kg-1 · h-1 maintain anesthesia （group L ） ,and propofol medium /long-chain fat e-mulsion injection 4 mg · kg-1 · h-1 maintain anesthesia （group M ） .The blood samples were collected after tracheal intubation （T1 ） and maintain 2 hours after infusion of propofol （T2 ） ,for the measure-ment of acetoacetate ,β-hydroxybutyrate and calculating blood ketone body ratio （The ratio of acetoace-tate and β-hydroxybutyrate） .Results All indexes between T1 and T2 time comparison ,there were no statistically significant differences （ P〉 0 .05 ） .Conclusion Propofol long-chain fat emulsion injection and propofol medium /long-chain fat emulsion injection short time continuous infusion has no obvious effect on hepatic energy metabolism .