| 氯米帕明和阿米替林治疗70例抑郁症的对照试验 |
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| 引用本文： | 赵靖平,陈远光,张宏根,张淑云,丁杰豪.氯米帕明和阿米替林治疗70例抑郁症的对照试验[J].中国新药与临床杂志,1991(6). |
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| 作者姓名： | 赵靖平 陈远光 张宏根 张淑云 丁杰豪 |
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| 作者单位： | 湖南医科大学精神卫生研究所，湖南医科大学精神卫生研究所，湖南省精神病医院，湖南省精神病医院，湖南省精神病医院 长沙 410011，长沙 410011，长沙 410007，长沙 410007，长沙 410007 |
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| 摘 要： | 报道国产氯米帕明(男21例,女14例,年龄83±11yr)和阿米替林(男16例,女19例,年龄33±12yr)治疗70例抑郁症的对照试验。1wk内加至150-250mg/d共4wk。结果显示抗抑郁疗效2药间无显著差异。汉密顿抑郁量表总分的减分氯米帕明组大于阿米替林组(分别为29±9,24±13,P<0.05)。2药主要副作用为口干、便秘、心悸、头晕等抗胆碱能作用,氯米帕明副作用略轻于阿米替林。
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| 关 键 词： | 氯米帕明/治疗应用 阿米替林/治疗应用 抑郁障碍症/药物疗法 |
A comparative trial of clomipramine and amitriptyline in seventy depressive disorder patients |
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| ZHAO Jing-Ping,CHEN Yuan-Guang.A comparative trial of clomipramine and amitriptyline in seventy depressive disorder patients[J].Chinese Journal of New Drugs and Clinical Remedies,1991(6). |
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| Authors: | ZHAO Jing-Ping CHEN Yuan-Guang |
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| Abstract: | This paper reports a control study of clomipramine (M 21, F 14, age 33±11 yr) and amitriptyline (M 16, F 19, age 33±12 yr) for treatment on seventy depressive patients. By gradual increase of the dose to 150-250 mg/d within 1 wk for. 4 wk, the results showed that clomipramine had better antidepressive efficacy than amitriptyline, but without statistical significance. The decrease of HDS total scores of clomipramine and amitriptyline were 29±9 and 24±13 respectively, P<0.05. The common side effects of both drugs are anticholinergic effects, and clomipramine has lesser adverse reactions than amitriptyline. |
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| Keywords: | clomipramine/therapeutic use: amitriptyline/therapeutic use: depressive disorder/drug therapy |
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